Cleanse thoroughly before applying. Apply Zapzyt Acne Treatment Gel to areas where pimples and excess oil occurs. Apply Zapzyt before using moisturizers or makeup, do not rinse. If excessive drying of the skin occurs, reduce applications to once a day, or every other day. For best results use up to three times daily. Once your skin has cleared, continue using Zapzyt to keep new pimples from forming. Store at room temperature 15-30 degrees C (59-86 degrees F).